Le Grand Fabien, Rudnicki Michael A
Sprott Center for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, K1H 8L6 Ontario, Canada.
Curr Opin Cell Biol. 2007 Dec;19(6):628-33. doi: 10.1016/j.ceb.2007.09.012. Epub 2007 Nov 8.
Research focusing on the canonical adult myogenic progenitor, the skeletal muscle satellite cell, is still an ever-growing field 46 years from their initial description. Recent publications revealed numerous new aspects of satellite cell biology, starting from their developmental life to their role as the principal self-renewing myogenic stem cell in adult skeletal muscle and finally their loss during aging. The myogenic potential of satellite cells is under the molecular control of specific paired-box and bHLH transcription factors whose tightly orchestrated balance accounts for an effective skeletal muscle regeneration. New reports also demonstrate satellite cells relationships with blood vessels and the high myogenic potential of stem cell subsets related to both lineages.
聚焦于典型成年肌源性祖细胞——骨骼肌卫星细胞的研究，自其最初被描述以来的46年间仍是一个不断发展的领域。最近的出版物揭示了卫星细胞生物学的许多新方面，从它们的发育历程到它们作为成年骨骼肌中主要的自我更新肌源性干细胞的作用，以及最终它们在衰老过程中的丧失。卫星细胞的肌源性潜能受特定配对盒和bHLH转录因子的分子控制，其精确协调的平衡有助于有效的骨骼肌再生。新的报告还证明了卫星细胞与血管的关系以及与这两个谱系相关的干细胞亚群的高肌源性潜能。
