Rørth Pernille
Temasek Life Sciences Laboratory (TLL), 1 Research link, National University of Singapore, 117604, Singapore.
Trends Cell Biol. 2007 Dec;17(12):575-9. doi: 10.1016/j.tcb.2007.09.007. Epub 2007 Nov 8.
Some cells migrate and find their way as solitary entities. However, during development of multicellular animals and possibly during tumor dissemination, cells often move as groups, associated tightly or loosely. Recent advances in live imaging have aided examination of such 'multicellular cell biology'. Here, I propose a model for how a group of cells can process and react to guidance information as a unit rather than as a gathering of solitary cells. Signaling pathways and regulatory mechanisms can differ substantially between solitary- and collective-guidance modes; a major difference being that, in collective guidance, similar to in bacterial chemotaxis, the signal need not be localized subcellularly within the responding cell. I suggest that collective-guidance signaling occurs alongside individual cell reactions. Both produce directional migration.
一些细胞作为单独的个体进行迁移并找到它们的路径。然而，在多细胞动物的发育过程中，可能也在肿瘤扩散期间，细胞常常以群体形式移动，紧密或松散地联系在一起。实时成像技术的最新进展有助于对这种“多细胞细胞生物学”进行研究。在这里，我提出了一个模型，用于解释一组细胞如何作为一个整体而非单个细胞的集合来处理和响应引导信息。单独引导模式和集体引导模式之间的信号通路和调节机制可能有很大差异；一个主要区别在于，在集体引导中，类似于细菌趋化作用，信号不需要在响应细胞内进行亚细胞定位。我认为集体引导信号与单个细胞反应同时发生。两者都会产生定向迁移。
