McInerney Patricia A, Nicholas Patrice K, Wantland Dean, Corless Inge B, Ncama Busisiwe, Bhengu Busisiwe, McGibbon Chris A, Davis Sheila M, Gallagher Donna M
University of KwaZulu Natal, Durban 4004, South Africa.
Appl Nurs Res. 2007 Nov;20(4):164-70. doi: 10.1016/j.apnr.2006.06.006.
Adherence to anti-tuberculosis (TB) medications is a critical issue in limiting the spread of the disease throughout the world. In South Africa, medications to treat TB are available at no cost. The purpose of this study was to examine the characteristics of medication adherence in a sample of patients diagnosed with TB (N = 159). The relationships among sociodemographic variables, social support, quality of life, and adherence were explored in this cross-sectional and descriptive study. Self-report data were obtained from a community-based sample of TB-infected individuals who received care in outpatient clinics in Durban, South Africa. Data were collected from the 159 Zulu- and/or English-speaking respondents who agreed to participate in the study. Logistic regression analyses indicated that 41% of the variance in adherence was explained by the model, with nonadherent participants more likely to have less frequent symptoms and more available nutrition than their adherent counterparts. The adherent group was more likely to have increased symptoms, more days with nothing to eat, and fewer appointments with their health care provider. Implications for clinical practice and research are discussed.
坚持服用抗结核药物是限制该病在全球传播的一个关键问题。在南非，治疗结核病的药物是免费提供的。本研究的目的是在一组被诊断为结核病的患者样本（N = 159）中检查药物依从性的特征。在这项横断面描述性研究中，探讨了社会人口统计学变量、社会支持、生活质量和依从性之间的关系。自我报告数据来自南非德班门诊接受治疗的社区结核病感染个体样本。数据收集自159名同意参与研究的讲祖鲁语和/或英语的受访者。逻辑回归分析表明，该模型解释了41%的依从性方差，与依从性参与者相比，不依从的参与者症状出现频率更低，营养供应更充足。依从性组更有可能出现症状加重、更多天没东西吃以及与医疗服务提供者的预约更少。文中讨论了对临床实践和研究的启示。
