Corless Inge B, Wantland Dean, Bhengu Busi, McInerney Patricia, Ncama Busi, Nicholas Patrice K, McGibbon Chris, Wong Emily, Davis Sheila M
Graduate Program in Nursing, MGH Institute of Health Professions, Boston, MA, USA.
AIDS Care. 2009 Sep;21(9):1106-13. doi: 10.1080/09540120902729932.
Given that antiretroviral (ARV) medication adherence has been shown to be high in resource-limited countries, the question remains as to whether adherence will remain at that level as medications become more widely available. Comparing adherence to tuberculosis (TB) medications, which have been readily available, and ARV medications may help to indicate the likely future adherence to ARVs as access to these medications becomes more widespread. This study examined sense of coherence, social support, symptom status, quality of life, and adherence to medications in two samples of individuals being treated either for TB or human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at clinics in Durban, South Africa. Findings revealed the distinctive socio-economic backgrounds of the two cohorts. Although there were significant differences with regard to the psychosocial variables, there were no significant differences by the two samples in adherence to medications as well as adherence to appointments. Given the self-selected nature of the participants in this study, namely those able to attend clinic, as well as those likely to be adherent to ARVs, there is every reason for caution in the interpretations of these findings. As access to ARV medications becomes more widely available in South Africa, the question remains as to whether such high adherence will be maintained given the constraints of access to food and other basic necessities.
鉴于抗逆转录病毒（ARV）药物的依从性在资源有限的国家已被证明很高，随着药物的可及性越来越广泛，依从性是否会维持在该水平仍是个问题。比较对抗结核（TB）药物（已很容易获得）的依从性和对抗逆转录病毒药物的依从性，可能有助于表明随着这些药物的可及性越来越广泛，未来对抗逆转录病毒药物的依从性情况。本研究在南非德班的诊所中，对接受结核病或人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）治疗的两组个体样本的连贯感、社会支持、症状状况、生活质量和药物依从性进行了调查。研究结果揭示了这两组人群独特的社会经济背景。虽然在心理社会变量方面存在显著差异，但两组样本在药物依从性和就诊依从性方面没有显著差异。鉴于本研究中参与者的自我选择性质，即那些能够前往诊所就诊的人以及那些可能对抗逆转录病毒药物依从的人，对这些研究结果的解读需谨慎。随着抗逆转录病毒药物在南非的可及性越来越广泛，鉴于获取食物和其他基本必需品的限制，如此高的依从性是否会维持仍是个问题。
