Yang X, Manninen H, Naukkarinen A, Ji H, Kankkunen J P, Suhonen M, Soimakallio S
Department of Clinical Radiology, Kuopio University Central Hospital, Finland.
J Vasc Interv Radiol. 1991 Feb;2(1):159-65. doi: 10.1016/s1051-0443(91)72492-5.
CO2 gas has been proposed as a new perfusion medium for laser angioplasty. To compare CO2 gas with conventional saline perfusion, 146 fresh specimens of normal and atheromatous human artery were irradiated with a neodymium: yttrium-aluminum-garnet laser with a sapphire probe in flowing whole blood in an experimental circulation-occlusion model. The dimensions of the ablation crater and the extent of the surrounding tissue damage were measured microscopically. Significantly better ablation of atheromatous plaque was achieved with CO2 perfusion than with saline perfusion: mean ablation areas were 5.0 mm2 versus 2.8 mm2, respectively (P = .001, Student t test). In contrast, the ablation areas on normal vessel wall were identical (mean, 3.4 mm2) with the two perfusion media. Moreover, CO2 gas functioned as a negative contrast agent and facilitated direct monitoring of the laser recanalization procedure. On an experimental basis, CO2 gas perfusion seems to improve the efficiency and safety of laser ablation in human arteries.
二氧化碳气体已被提议作为激光血管成形术的一种新型灌注介质。为了将二氧化碳气体与传统的生理盐水灌注进行比较，在一个实验性循环阻塞模型中，使用配有蓝宝石探头的钕：钇铝石榴石激光，在流动的全血中对146个正常和动脉粥样硬化的人体动脉新鲜标本进行照射。通过显微镜测量消融坑的尺寸和周围组织损伤的程度。与生理盐水灌注相比，二氧化碳灌注在动脉粥样硬化斑块消融方面效果显著更好：平均消融面积分别为5.0平方毫米和2.8平方毫米（P = 0.001，学生t检验）。相比之下，两种灌注介质对正常血管壁的消融面积相同（平均为3.4平方毫米）。此外，二氧化碳气体起到了阴性造影剂的作用，有助于直接监测激光再通手术。基于实验，二氧化碳气体灌注似乎能提高人体动脉激光消融的效率和安全性。
