Thornburg Courtney D, Smith P Brian, Smithwick Mary Laura, Cotten C Michael, Benjamin Daniel K
Department of Pediatrics, Duke University, Durham, NC, USA.
Thromb Res. 2008;122(6):782-5. doi: 10.1016/j.thromres.2007.10.001. Epub 2007 Nov 13.
Peripherally inserted catheters are essential for infants in the neonatal intensive care nursery for administration of medications, parenteral nutrition and blood transfusions. We hypothesized that there is an association between catheter associated thrombosis and catheter associated blood stream infection. The primary objective of this study was to determine the association between catheter associated blood stream infection (CABSI) and catheter-related thrombosis in the Neonatal Intensive Care Unit.
We performed a cohort study of the 1540 peripherally inserted catheters placed in 882 infants from August 2002 until November 2005 in the Duke University Medical Center Neonatal Intensive Care Unit.
212 peripherally inserted catheters were removed because of thrombosis. We identified 142 cases of CABSI. There was a positive association between thrombosis and infection in infants who did not have lines removed for infection, p<0.05.
Further study is warranted to determine the pathophysiology between the association between thrombosis and infection and to determine if interventions may decrease the risk of these potentially life-threatening complications.
外周静脉置入导管对于新生儿重症监护病房中的婴儿进行药物输注、肠外营养支持及输血治疗至关重要。我们推测导管相关血栓形成与导管相关血流感染之间存在关联。本研究的主要目的是确定新生儿重症监护病房中导管相关血流感染（CABSI）与导管相关血栓形成之间的关联。
我们对2002年8月至2005年11月期间在杜克大学医学中心新生儿重症监护病房为882名婴儿置入的1540根外周静脉导管进行了一项队列研究。
212根外周静脉置入导管因血栓形成而被拔除。我们共识别出142例CABSI。在未因感染而拔除导管的婴儿中，血栓形成与感染之间存在正相关，p<0.05。
有必要进一步研究以确定血栓形成与感染之间关联的病理生理学机制，并确定干预措施是否可以降低这些潜在危及生命并发症的风险。
