亚烷基茚满及相关骨架的制备及其向新型化学类型的进一步衍生
Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes.
作者信息
Kesavan Sarathy, Panek James S, Porco John A
机构信息
Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
出版信息
Org Lett. 2007 Dec 6;9(25):5203-6. doi: 10.1021/ol7023778. Epub 2007 Nov 13.
PMID:17997565
Abstract
Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further diversification using consecutive cyclopropanation-Cope rearrangement affords novel chemotypes including spiroindane frameworks.
摘要
亚烷基茚满和扩环骨架已通过对映选择性巴豆酰化/Heck环化序列制备而成。利用连续的环丙烷化-Cope重排进行进一步多样化，可得到包括螺茚满骨架在内的新型化学结构类型。
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