Kitawaki Jo, Xu Bing, Ishihara Hiroaki, Fukui Michiaki, Hasegawa Goji, Nakamura Naoto, Mizuno Shigeto, Ohta Mitsuhiro, Obayashi Hiroshi, Honjo Hideo
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Am J Reprod Immunol. 2007 Dec;58(6):481-6. doi: 10.1111/j.1600-0897.2007.00533.x.
Endometriosis is an immune-related chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether polymorphisms in killer cell immunoglobulin-like receptors (KIRs) is responsible, in part, for genetic susceptibility to endometriosis.
The KIRs genotype was determined in 186 patients with endometriosis and 165 control women using polymerase chain reaction with sequence-specific primers.
The frequency of KIR3DS1 was significantly decreased in patients compared with controls (32% versus 44%, P=0.028). KIR data were analyzed using a model comprised of three large groups, in which a gradient of activation/inhibitory potential derived from the combination of KIR and human leukocyte antigen (HLA) ligand genes was taken into account. The frequency of inhibitory KIRs/HLA-class I combination genotypes was significantly higher in patients than in controls (chi2=6.010, 2 df, P=0.0496).
Our results suggest that polymorphism in KIRs may be associated with susceptibility for endometriosis.
子宫内膜异位症是一种具有多基因易感性的免疫相关慢性炎症性疾病。本研究的目的是调查杀伤细胞免疫球蛋白样受体（KIRs）基因多态性是否部分导致子宫内膜异位症的遗传易感性。
采用序列特异性引物聚合酶链反应，对186例子宫内膜异位症患者和165例对照女性进行KIRs基因型测定。
与对照组相比，患者中KIR3DS1的频率显著降低（32%对44%，P=0.028）。使用由三个大组组成的模型分析KIR数据，该模型考虑了KIR和人类白细胞抗原（HLA）配体基因组合产生的激活/抑制潜力梯度。患者中抑制性KIRs/HLA-I类组合基因型的频率显著高于对照组（χ2=6.010，2自由度，P=0.0496）。
我们的结果表明，KIRs基因多态性可能与子宫内膜异位症的易感性有关。
