Soltani Samaneh, Mostafaei Shayan, Aslani Saeed, Farhadi Elham, Mahmoudi Mahdi
Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, PO-BOX: 1411713137, Kargar Ave., Tehran, Iran.
Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Sorkheh-Ligeh Blvd, Kermanshah, Iran.
J Diabetes Metab Disord. 2020 Jul 9;19(2):1777-1786. doi: 10.1007/s40200-020-00569-2. eCollection 2020 Dec.
Type 1 Diabetes (T1D) is a T cell-mediated disease, in which autoimmune destruction of insulin-producing β-cells in pancreatic islets occurs. In recent decades, the role of Killer cell immunoglobulin-like receptor () gene polymorphisms in susceptibility to T1D has been demonstrated in an increased number of studies. Nonetheless, inconsistency has been observed in the results of performed association studies. To comprehensively clarify the association among gene polymorphisms and the risk of T1D, this meta-analysis on the previously published association studies was carried out via incorporating multiple research.
No publication has been recorded from Nov 2017 until July 2020 about the KIR genes and T1D. The PubMed/MEDLINE and Scopus databases were systematically searched up to November 2017 to identify investigations on the impact of the polymorphisms of genes on susceptibility to T1D. The odds ratio (OR) with a 95% confidence interval (95% CI) was calculated. Funnel plot and Egger test were used to assess the publication bias. Thirteen qualified published case-control articles were found for evaluation in this meta-analysis.
Our results show statistical significance between the genetic variations in the (OR = 0.42, 95% CI = 0.23-0.77; = 0.005), (OR = 1.15, 95% CI = 1.00-1.32; = 0.048), and (OR = 0.86, 95% CI = 0.75-0.98; = 0.03) with susceptibility to T1D.
This meta-analysis study provides reliable evidence that gene polymorphisms may contribute to T1D risk. and genes might be considered as a protective factor for T1D, while seemed to be a susceptibility factor.
1型糖尿病（T1D）是一种T细胞介导的疾病，其中胰岛中产生胰岛素的β细胞会发生自身免疫性破坏。近几十年来，越来越多的研究表明杀伤细胞免疫球蛋白样受体（KIR）基因多态性在T1D易感性中的作用。然而，已进行的关联研究结果存在不一致性。为了全面阐明KIR基因多态性与T1D风险之间的关联，通过纳入多项研究，对先前发表的关联研究进行了这项荟萃分析。
2017年11月至2020年7月期间未记录到关于KIR基因与T1D的出版物。截至2017年11月，对PubMed/MEDLINE和Scopus数据库进行了系统检索，以确定关于KIR基因多态性对T1D易感性影响的研究。计算了比值比（OR）及95%置信区间（95%CI）。采用漏斗图和Egger检验评估发表偏倚。在这项荟萃分析中，发现了13篇合格的已发表病例对照文章进行评估。
我们的结果显示，KIR2DL1（OR = 0.42，95%CI = 0.23 - 0.77；P = 0.005）、KIR3DL1（OR = 1.15，95%CI = 1.00 - 1.32；P = 0.048）和KIR3DS1（OR = 0.86，95%CI = 0.75 - 0.98；P = 0.03）的基因变异与T1D易感性之间具有统计学意义。
这项荟萃分析研究提供了可靠的证据，表明KIR基因多态性可能与T1D风险有关。KIR2DL1和KIR3DS1基因可能被视为T1D的保护因素，而KIR3DL1似乎是一个易感因素。
