Huyck Karen L, Kile Molly L, Mahiuddin Golam, Quamruzzaman Quazi, Rahman Mahmuder, Breton Carrie V, Dobson Christine B, Frelich Janna, Hoffman Elaine, Yousuf Jabed, Afroz Sakila, Islam Shofiqul, Christiani David C
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
J Occup Environ Med. 2007 Oct;49(10):1097-104. doi: 10.1097/JOM.0b013e3181566ba0.
To characterize the effects of maternal arsenic exposure on birth weight.
Hair, toenail, and drinking water samples were collected from pregnant women (n = 52) at multiple time points during pregnancy and from their newborns after birth. Total arsenic was measured using inductively coupled plasma-mass spectrometry. The association between arsenic and birth weight was investigated using linear and logistic regression models.
Maternal hair arsenic measured early in pregnancy was associated with decreased birth weight (beta = -193.5 +/- 90.0 g, P = 0.04). Maternal hair and drinking water arsenic levels measured at first prenatal visit were significantly correlated with newborn hair arsenic level (rho = 0.32, P = 0.04 and rho = 0.31, P = 0.04).
Results suggest that maternal arsenic exposure early in pregnancy negatively affects newborn birth weight and that maternal hair provides the best integrated measure of arsenic exposure.
描述孕期母亲砷暴露对出生体重的影响。
在孕期多个时间点收集52名孕妇及其新生儿出生后的头发、 toenail和饮用水样本。使用电感耦合等离子体质谱法测量总砷含量。使用线性和逻辑回归模型研究砷与出生体重之间的关联。
孕期早期测量的母亲头发砷含量与出生体重降低有关（β=-193.5±90.0克，P=0.04）。首次产前检查时测量的母亲头发和饮用水砷水平与新生儿头发砷水平显著相关（ρ=0.32，P=0.04；ρ=0.31，P=0.04）。
结果表明，孕期早期母亲砷暴露对新生儿出生体重有负面影响，母亲头发是砷暴露的最佳综合测量指标。
