Dong Jiaxiang, Liu Ping, Zhang Aili, Xu Lisa X
Department of Biomedical Engineering, School of Life Science and Technology, Shanghai Jiao Tong University, PR China.
Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:1491-4. doi: 10.1109/IEMBS.2007.4352583.
A new in-situ thermal physical method combining both cryosurgery and local hyperthermia was used to treat mice bearing 4T1 murine mammary carcinoma. The induced anti-tumor immune response was investigated. The cryo/heat treatment resulted in stimulation of CTL response and attraction of immunocytes into the tumor debris, which correlated well to the tumor rejection in re-implantation. The results suggested that alternated cooling and heating had synergistic effect and might be developed into an alternative modality for tumor therapy.
一种结合冷冻手术和局部热疗的新型原位热物理方法被用于治疗携带4T1小鼠乳腺癌的小鼠。研究了诱导的抗肿瘤免疫反应。冷冻/热疗导致CTL反应的刺激和免疫细胞向肿瘤碎片的吸引，这与再植入时的肿瘤排斥密切相关。结果表明，交替冷却和加热具有协同作用，可能发展成为一种替代的肿瘤治疗方式。
