乳腺癌皮肤转移的冷冻手术与热疗联合治疗：一例报告
Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report.
作者信息
Hachisuka Junichi, Doi Kazuko, Furue Masutaka
机构信息
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Int J Surg Case Rep. 2012;3(2):68-9. doi: 10.1016/j.ijscr.2011.10.016. Epub 2011 Nov 10.
INTRODUCTION
Skin metastases may impair the quality of life due to physical appearance, odour, and bleeding.
PRESENTATION OF CASE
A 70-year-old woman presented with two enlarging nodules (measuring 12 cm and 3 cm in diameter) consistent with metastatic breast cancer in the left subclavicular area. The larger tumour did not respond to initial cryosurgery. Therefore we added hyperthermia using a disposable body warmer. In addition, the cryosurgery technique was modified to freeze deeper tissue. The entire tumour was covered with dry cotton, to which liquid nitrogen was applied. Twenty weeks later, the tumour became nearly flat and the patient noted improved activity in her daily life.
DISCUSSION
Combination treatment with sufficient freezing is important for controlling the tumour, while hyperthermia may accelerate the antitumor effects of cryosurgery.
CONCLUSION
[corrected] This treatment provides an alternative for unresectable breast cancer skin metastases resistant to chemotherapy and radiotherapy.
引言
皮肤转移瘤可能因外观、气味和出血而损害生活质量。
病例介绍
一名70岁女性，左锁骨下区域出现两个不断增大的结节（直径分别为12厘米和3厘米），符合转移性乳腺癌表现。较大的肿瘤对初始冷冻手术无反应。因此，我们使用一次性身体保暖器增加了热疗。此外，对冷冻手术技术进行了改进，以冷冻更深的组织。整个肿瘤用干棉花覆盖，然后在棉花上施加液氮。二十周后，肿瘤几乎变平，患者注意到其日常生活活动有所改善。
讨论
充分冷冻的联合治疗对于控制肿瘤很重要，而热疗可能会加速冷冻手术的抗肿瘤效果。
结论
这种治疗方法为对化疗和放疗耐药的不可切除乳腺癌皮肤转移瘤提供了一种替代方案。
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