Ito Yoshiyuki, Kurokawa Ichiro, Nishimura Keisuke, Hakamada Arata, Isoda Ken-ichi, Yamanaka Kei-ichi, Tsubura Airo, Mizutani Hitoshi
Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.
J Eur Acad Dermatol Venereol. 2008 Mar;22(3):353-5. doi: 10.1111/j.1468-3083.2007.02440.x. Epub 2007 Nov 12.
To clarify the histogenesis of keratoacanthoma, we studied keratin (K) expression in keratoacanthoma (KA) using 10 different anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18 and K19 and anti-filaggrin (filament aggregating protein) antibody. In the centre of KA, K1 and K10 expressions were declined, and K14 and K16 were detected in the tumour cells, suggesting differentiation towards the outer root sheath beneath the orifice of the sebaceous duct. These results suggest that KA differentiates towards the outer root sheath beneath the opening of the sebaceous duct.
为阐明角化棘皮瘤的组织发生，我们使用10种不同的抗角蛋白抗体（针对K1、K7、K8、K10、K14、K15、K16、K17、K18和K19）及抗丝聚蛋白（细丝聚集蛋白）抗体研究了角化棘皮瘤（KA）中的角蛋白（K）表达。在KA中央，K1和K10表达下降，肿瘤细胞中检测到K14和K16，提示向皮脂腺导管开口下方的外根鞘分化。这些结果表明KA向皮脂腺导管开口下方的外根鞘分化。
