Department of Surgical Sciences, Division of Pathology, University of Cagliari, Italy.
Eur J Histochem. 2013 Feb 14;57(1):e6. doi: 10.4081/ejh.2013.e6.
The protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. The purpose of this study is to compare IMP3 immunostaining in squamous cellular skin tumor and determine whether IMP3 can aid in the differential diagnosis of these lesions. To our knowledge, IMP3 expression has not been investigated in skin squamous cell proliferations thus far. Immunohistochemical staining for IMP3 was performed on slides organized by samples from 67 patients, 34 with keratoacanthoma and 33 with primary squamous cell carcinoma (16 invasive and 17 in situ). The majority of our KAs (25/34) were negative for IMP-3 staining. The majority of SCCs (19/33) are positive for IMP3 staining. The percentage of IMP3 positive cells increases significantly in group SCC (p=0.0111), and in particular in the SCC in situ group (p=0.0021) with respect to the KA group. IMP3 intensity staining increases significantly in SCCs (p=0.0213), and particularly in SCCs (p=0.008) with respect to KA. Our data show that IMP3 expression is different in keratoacanthomas with respect to squamous cell carcinoma. IMP3 assessment and staining pattern, together with a careful histological study, can be useful in the differential diagnosis between KA e SCC.
胰岛素样生长因子 II mRNA 结合蛋白 3（IMP3）是恶性肿瘤中细胞迁移和黏附的重要因素。最近的研究表明，IMP3 在不同的人类恶性肿瘤中显著过表达，并且在一些肿瘤实体中也被揭示为重要的预后标志物。本研究的目的是比较鳞状细胞皮肤肿瘤中的 IMP3 免疫染色，并确定 IMP3 是否有助于这些病变的鉴别诊断。据我们所知，迄今为止，IMP3 在皮肤鳞状细胞增生中的表达尚未被研究过。对 67 名患者的样本进行了 IMP3 免疫组织化学染色，其中 34 名患者为角化棘皮瘤，33 名患者为原发性鳞状细胞癌（16 名侵袭性和 17 名原位）。我们的大多数角化棘皮瘤（25/34）IMP-3 染色为阴性。大多数鳞状细胞癌（19/33）IMP3 染色阳性。与 KA 组相比，SCC 组（p=0.0111），特别是 SCC 原位组（p=0.0021）IMP3 阳性细胞的百分比明显增加。与 KA 相比，SCCs（p=0.0213）和尤其是 SCCs（p=0.008）中 IMP3 强度染色明显增加。我们的数据表明，IMP3 在角化棘皮瘤与鳞状细胞癌中的表达不同。IMP3 评估和染色模式，结合仔细的组织学研究，可用于 KA 和 SCC 之间的鉴别诊断。
