McNiff Jennifer M, Kaplan Daniel H
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
J Cutan Pathol. 2008 May;35(5):452-6. doi: 10.1111/j.1600-0560.2007.00848.x. Epub 2007 Nov 12.
Plasmacytoid dendritic cells (PDCs) are CD123-positive dendritic cells (DCs) capable of producing interferon-alpha (IFN). They are thought to play a role in anti-viral immunity and the pathogenesis of lupus erythematosus (LE). Given the histologic similarities between LE and dermatomyositis (DM), we evaluated the presence and distribution of PDCs in lesional skin of both diseases.
Twenty-eight biopsies of DM and 27 biopsies of LE were labeled with antibodies to CD123 to identify PDCs. The presence and relative distribution of CD123+ cells was recorded.
PDCs are present in LE and DM, albeit in greater numbers in LE lesions. Interestingly, PDCs are preferentially located in the epidermis of DM, and are primarily located in the dermis of LE.
Skin lesions of DM contain PDCs. Because PDCs are thought to participate in the pathogenesis of LE, this finding suggests that they may play a role in DM as well. The preferential epidermal localization of PDCs in DM suggests that their contribution to disease pathogenesis or maintenance in DM may be distinct from LE. Finally, although not pathognomonic, the different patterns of PDC localization in LE and DM may prove a helpful criterion for distinguishing between these two entities histologically.
浆细胞样树突状细胞（pDCs）是CD123阳性的树突状细胞（DCs），能够产生α干扰素（IFN）。它们被认为在抗病毒免疫和红斑狼疮（LE）的发病机制中发挥作用。鉴于LE和皮肌炎（DM）在组织学上有相似之处，我们评估了这两种疾病皮损中pDCs的存在情况和分布。
对28例DM活检组织和27例LE活检组织用抗CD123抗体进行标记，以识别pDCs。记录CD123+细胞的存在情况和相对分布。
pDCs存在于LE和DM中，尽管在LE皮损中的数量更多。有趣的是，pDCs在DM中优先位于表皮，而在LE中主要位于真皮。
DM的皮肤病变中含有pDCs。由于pDCs被认为参与LE的发病机制，这一发现表明它们可能在DM中也发挥作用。pDCs在DM中优先定位于表皮，提示它们对DM疾病发病机制或维持的作用可能与LE不同。最后，尽管不具有诊断特异性，但pDCs在LE和DM中的不同定位模式可能在组织学上为区分这两种疾病提供一个有用的标准。
