Krishnamurthy Suganthi, Tirumalae Rajalakshmi, Inchara Y K
St. John's Medical College, John Nagar, Bangalore - 560034, India.
J Cutan Aesthet Surg. 2022 Apr-Jun;15(2):179-182. doi: 10.4103/JCAS.JCAS_126_19.
Classification of scarring alopecia poses a major problem, as there is considerable clinicopathologic overlap, particularly between lupus erythematosus (LE) and lichen planopilaris (LPP), especially in later stages. CD123 positive plasmacytoid dendritic cells (PDC) have been shown recently to be present in all forms of LE and are touted to be useful in differentiating LE from other scarring alopecias. Their distribution in non-scarring alopecia is not well documented. This is the first study that examines the PDC in both scarring and non-scarring alopecias.
To study the expression patterns of PDC in cases of both scarring and non-scarring alopecia.
A total of 69 cases of alopecia (48 scarring, 21 non-scarring) were studied for CD123 expression by immunohistochemistry.
Among the scarring alopecias, 17/20 LE cases showed PDC in contrast to 1/22 LPP cases. This difference was statistically significant ( = 0.0001). 1/2 cases of folliculitis decalvans showed PDC. None of the cases of unclassified scarring alopecia were positive. In the non-scarring group, 19/20 cases of alopecia areata and a single case of trichotillomania lacked PDC.
The finding of CD123 expressing PDC appears to be a promising parameter in distinguishing LE from other forms of alopecia.
瘢痕性脱发的分类是一个主要问题，因为存在相当多的临床病理重叠，特别是在红斑狼疮（LE）和扁平苔藓性秃发（LPP）之间，尤其是在后期。最近发现CD123阳性浆细胞样树突状细胞（PDC）存在于所有形式的LE中，并被认为有助于将LE与其他瘢痕性脱发区分开来。它们在非瘢痕性脱发中的分布尚无充分记录。这是第一项研究瘢痕性和非瘢痕性脱发中PDC的研究。
研究瘢痕性和非瘢痕性脱发病例中PDC的表达模式。
通过免疫组织化学研究了总共69例脱发病例（48例瘢痕性，21例非瘢痕性）的CD123表达。
在瘢痕性脱发中，20例LE病例中有17例显示有PDC，而22例LPP病例中只有1例显示有PDC。这种差异具有统计学意义（P = 0.0001）。2例脱发性毛囊炎中有1例显示有PDC。未分类的瘢痕性脱发病例均为阴性。在非瘢痕性组中，20例斑秃中有19例和1例拔毛癖病例没有PDC。
发现表达CD123的PDC似乎是区分LE与其他形式脱发的一个有前景的参数。
