Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA.
Judith & Stewart Colton Center for Autoimmunity, Department of Medicine Research, NYU Grossman School of Medicine, New York, New York, USA.
J Invest Dermatol. 2022 Mar;142(3 Pt B):793-803. doi: 10.1016/j.jid.2021.11.031. Epub 2022 Jan 10.
Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies targeting IFN-1 pathways. In this review, we provide an overview of the signaling pathway and immune functions of IFN-1s in health and disease. We also review the systemic autoimmune diseases classically associated with IFN-1 upregulation and current therapeutic strategies targeting the IFN-1 system.
失调的 IFN-1 反应在多种自身免疫性疾病的发展中起着关键作用。许多狼疮、系统性硬化症、干燥综合征和皮肌炎患者表现出增强的 IFN-1 信号。IFN-1 过多与疾病严重程度和自身抗体有关，并可能预测对针对 IFN-1 途径的新型治疗方法的反应。在这篇综述中，我们提供了 IFN-1 在健康和疾病中的信号通路和免疫功能的概述。我们还回顾了与 IFN-1 上调相关的经典系统性自身免疫性疾病和目前针对 IFN-1 系统的治疗策略。
