Arbibe Laurence, Sansonetti Philippe J
Unité de Pathogénie Microbienne Moléculaire and Unité INSERM 786, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France.
Cell Host Microbe. 2007 Jun 14;1(4):244-6. doi: 10.1016/j.chom.2007.05.011.
Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflammatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation.
对脂多糖（LPS）的耐受性是宿主在革兰氏阴性共生菌和病原体存在时避免有害过度炎症的策略的一部分。巨噬细胞是具有这种特性的主要细胞，使它们能够在维持有效抗菌功能的同时限制促炎基因的表达。在最近的一篇论文中，福斯特等人（2007年）证明这种微妙的平衡是通过表观遗传调控建立和印记的。
