INSERM, U895, Toxines Microbiennes dans la Relation Hôte Pathogènes, Centre Méditerranéen de Médecine Moléculaire, C3M, Nice, 06204, Cedex 3, France.
Nat Rev Microbiol. 2010 Feb;8(2):93-104. doi: 10.1038/nrmicro2269. Epub 2009 Dec 30.
The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of pathogenic bacteria. Endothelial cells are actively involved in host responses to infectious agents, producing inflammatory cytokines, controlling coagulation cascades and regulating leukocyte trafficking. In this Review, a range of bacteria and bacterial toxins are used to illustrate how pathogens establish intimate interactions with endothelial cells, triggering inflammatory responses and coagulation processes and modifying endothelial cell plasma membranes and junctions to adhere to their surfaces and then invade, cross and even disrupt the endothelial barrier.
血管和淋巴管的内皮衬里是将体液与宿主组织分隔开的关键屏障，也是致病菌的主要靶点。内皮细胞积极参与宿主对感染因子的反应，产生炎症细胞因子，控制凝血级联反应，并调节白细胞的迁移。在这篇综述中，我们使用了一系列细菌和细菌毒素来说明病原体如何与内皮细胞建立密切的相互作用，引发炎症反应和凝血过程，并修饰内皮细胞的质膜和连接，以黏附在其表面，然后入侵、穿越甚至破坏内皮屏障。
