Selek Salih, Herken Hasan, Bulut Mahmut, Ceylan Mehmet F, Celik Hakim, Savas Haluk A, Erel Ozcan
Gaziantep University, Sahinbey Research Hospital, Psychiatry Department, Gaziantep/Turkey.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):487-91. doi: 10.1016/j.pnpbp.2007.10.002. Epub 2007 Oct 10.
Various psychological, social, genetic, biochemical, factors are to be involved in the etiology of OCD. Some molecules of free radicals are also found to play role in OCD. To the best of our knowledge, there has been no study, regarding the role of free radicals in the pathogenesis of OCD, from a general antioxidant aspect of view. Therefore, in this present cross-sectional study, we aimed to assess whether antioxidant-oxidant status is associated with OCD and can be used or not as a biological marker regarding that disorder.
37 OCD patients diagnosed according to DSM-IV and as control group forty healthy subjects were included to the study. Venous blood samples were collected once. The total oxidant status, antioxidant status and oxidative stress index of the plasma were measured using a novel automated colorimetric measurement method.
There was not a significant difference between only OCD and all patients in all measures (TOS: Z = - 1.453, p = 0.521; TAS: Z = - 0.151, p = 0.880; OSI: Z = - 0.679 p = 0.497). TAS levels were both higher than controls in only OCD groups and all patients (Z = - 5.538, p < 0.001 and Z = - 6.394, p < 0.001 respectively). TOS and OSI of both patient groups were significantly lower than controls (TOS: Z = - 5.131, p < 0.001; OSI: Z = - 5.105, p < 0.001 and TOS: Z = - 5.979, p < 0.001; OSI: Z = - 5.862, p < 0.001). In only OCD group, illness duration was correlated with TOS and OSI (r(0) = 0.44, p = 0.023, n = 26 and r(0) = 0.44, p = 0.026, n = 26 respectively) but not with TAS.
Our study found an overall oxidative imbalance shifted towards antioxidant side in OCD which may be due to either a rebound phenomenon or chronicity of the condition.
强迫症的病因涉及多种心理、社会、遗传、生化因素。一些自由基分子也被发现与强迫症有关。据我们所知，从一般抗氧化剂的角度来看，尚未有关于自由基在强迫症发病机制中作用的研究。因此，在本横断面研究中，我们旨在评估抗氧化 - 氧化状态是否与强迫症相关，以及是否可作为该疾病的生物学标志物。
本研究纳入了37例根据《精神疾病诊断与统计手册》第四版（DSM - IV）诊断的强迫症患者，并以40名健康受试者作为对照组。一次性采集静脉血样本。使用一种新型自动比色测量方法测量血浆的总氧化状态、抗氧化状态和氧化应激指数。
仅强迫症患者组与所有患者组在各项测量指标上均无显著差异（总氧化状态：Z = - 1.453，p = 0.521；总抗氧化状态：Z = - 0.151，p = 0.880；氧化应激指数：Z = - 0.679，p = 0.497）。仅强迫症患者组和所有患者组的总抗氧化状态水平均高于对照组（分别为Z = - 5.538，p < 0.001和Z = - 6.394，p < 0.001）。两组患者的总氧化状态和氧化应激指数均显著低于对照组（总氧化状态：Z = - 5.131，p < 0.001；氧化应激指数：Z = - 5.105，p < 0.001以及总氧化状态：Z = - 5.979，p < 0.001；氧化应激指数：Z = - 5.862，p < 0.001）。在仅强迫症患者组中，病程与总氧化状态和氧化应激指数相关（分别为r(0) = 0.44，p = 0.023，n = 26和r(0) = 0.44，p = 0.026，n = 26），但与总抗氧化状态无关。
我们的研究发现强迫症患者总体氧化失衡向抗氧化方向偏移，这可能是由于反弹现象或病情的慢性化所致。
