Zengil Sertaç, Laloğlu Esra
Department of Psychiatry, University of Health Sciences Erzurum Faculty of Medicine, Erzurum, Türkiye.
Department of Medical Biochemistry, Ataturk University Faculty of Medicine, Erzurum, Türkiye.
Front Psychiatry. 2024 Oct 15;15:1469640. doi: 10.3389/fpsyt.2024.1469640. eCollection 2024.
The aim of this study was to examine the levels of oxidant and antioxidant markers in patients with obsessive-compulsive disorder (OCD) and to investigate whether these levels change in the presence of major depressive disorder (MDD) comorbidity.
This study was completed with 23 OCD patients with MDD comorbidity (OCD+MDD), 21 OCD patients without MDD comorbidity (OCD-MDD) and 21 healthy controls. Oxidative stress levels of the cases' were determined by ischemia modified albumin (IMA) and malondialdehyde (MDA) measurements and antioxidant levels were determined by superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) measurements. One-way analysis of variance (ANOVA) and unpaired Student's t-test were used to compare the study groups. Bonferroni test was used for the degree of significance between groups, and repeated measures analysis of covariance (ANCOVA) was used to investigate the effect of age and gender.
IMA and MDA levels were significantly higher in the OCD group compared to the control group, and SOD, CAT and GSH-Px levels were lower in the OCD group compared to the control group (p<0.01). IMA levels were significantly higher in the OCD+MDD group compared to the OCD-MDD group, while SOD, CAT and GSH-Px levels were significantly lower in the OCD+MDD group compared to the OCD-MDD group (p<0101). MDA levels were significantly higher in the OCD+MDD group compared to the OCD-MDD group (p=0.009). When the entire OCD patient group was examined, significant, powerful, positive correlations were observed between Y-BOCS and HDRS scores and IMA and MDA, and significant powerful negative correlations between Y-BOCS and HDRS scores and SOD, CAT, and GSH-Px (p<0.001 for all). In OCD+MDD group, oxidative stress markers increased significantly in parallel with the severity of depression, while antioxidant levels decreased (p=0.003 for IMA, p<0.001 for others).
We believe that parameters indicating impaired oxidant/antioxidant balance in patients with obsessive-compulsive disorder may help to elucidate the cause of the disease and may be potentially useful biomarkers in the diagnosis and determination of the severity of comorbid MDD.
本研究旨在检测强迫症（OCD）患者的氧化剂和抗氧化剂标志物水平，并调查在合并重度抑郁症（MDD）时这些水平是否会发生变化。
本研究纳入了23例合并MDD的OCD患者（OCD+MDD）、21例未合并MDD的OCD患者（OCD-MDD）和21名健康对照者。通过检测缺血修饰白蛋白（IMA）和丙二醛（MDA）来确定病例的氧化应激水平，通过检测超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）来确定抗氧化剂水平。采用单因素方差分析（ANOVA）和非配对学生t检验对研究组进行比较。使用Bonferroni检验来确定组间的显著性程度，并采用重复测量协方差分析（ANCOVA）来研究年龄和性别的影响。
与对照组相比，OCD组的IMA和MDA水平显著更高，而OCD组的SOD、CAT和GSH-Px水平低于对照组（p<0.01）。与OCD-MDD组相比，OCD+MDD组的IMA水平显著更高，而OCD+MDD组的SOD、CAT和GSH-Px水平显著更低（p<0.01）。与OCD-MDD组相比，OCD+MDD组的MDA水平显著更高（p=0.009）。当对整个OCD患者组进行检查时，在Y-BOCS和HDRS评分与IMA和MDA之间观察到显著、强且正相关，而在Y-BOCS和HDRS评分与SOD、CAT和GSH-Px之间观察到显著、强且负相关（所有p<0.001）。在OCD+MDD组中，氧化应激标志物随着抑郁严重程度的增加而显著升高，而抗氧化剂水平降低（IMA为p=0.003，其他为p<0.001）。
我们认为，表明强迫症患者氧化/抗氧化平衡受损的参数可能有助于阐明疾病病因，并且可能是诊断和确定合并MDD严重程度的潜在有用生物标志物。
