Gadoth Natan
Department of Neurology, Maayanei Hayeshua Medical Center, Bnei - Barak, Israel.
Brain Dev. 2008 May;30(5):309-12. doi: 10.1016/j.braindev.2007.10.001. Epub 2007 Nov 14.
In recent years we are facing a dramatic rise in the use of "behind the counter" medications to combat aging and improve memory and life quality. Many parents to children with learning difficulties, behavioral aberrations and those who are diagnosed with developmental disorders such as attention deficit, poor motor coordination and pervasive disorder are frequently advised by both professionals and lay persons to supplement their children with fish oil and or commercial preparations of omega-3, omega-6, or both polyunsaturated fatty acids (PUFA) in various combinations. The common logic is that "being a natural product, even if it does not help it should be safe to use". Indeed, this statement may well be true. In this paper a short description of the basic biochemistry and physiology of PUFA will be followed by a critical review of the presently known "evidence based" data on the value of this popular supplementation. At present the theoretical basis for supplementing children with the developmental disorders mentioned above is shaky and the evidence for its efficacy is still in doubt.
近年来,我们面临着“柜台后”药物用于抗老化、改善记忆力和生活质量的使用量急剧上升的情况。许多有学习困难、行为异常的孩子的家长,以及那些被诊断患有发育障碍(如注意力缺陷、运动协调性差和广泛性障碍)的孩子的家长,经常被专业人士和非专业人士建议给他们的孩子补充鱼油和/或各种组合的ω-3、ω-6或两者多不饱和脂肪酸(PUFA)的商业制剂。常见的逻辑是“作为天然产品,即使没有帮助,使用起来也应该是安全的”。的确,这种说法很可能是正确的。在本文中,将首先简要描述PUFA的基本生物化学和生理学,然后对目前已知的关于这种流行补充剂价值的“循证”数据进行批判性回顾。目前,给上述发育障碍儿童补充营养的理论基础尚不稳固,其有效性的证据仍存疑问。