Boateng Samuel Y, Goldspink Paul H
The Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
Cardiovasc Res. 2008 Mar 1;77(4):667-75. doi: 10.1093/cvr/cvm048. Epub 2007 Oct 25.
The assembly of sarcomeric proteins into the highly organized structure of the sarcomere is an ordered and complex process involving an array of structural and associated proteins. The sarcomere has shown itself to be considerably more complex than ever envisaged and may be considered one of the most complex macromolecular assemblies in biology. Studies over the last decade have helped to put a new face on the sarcomere, and, as such, the sarcomere is being redefined as a dynamic network of proteins capable of generating force and signalling with other cellular compartments and metabolic enzymes capable of controlling many facets of striated myocyte biology.
肌节蛋白组装成高度有序的肌节结构是一个有序且复杂的过程，涉及一系列结构蛋白和相关蛋白。肌节已显示出比以往设想的要复杂得多，可被视为生物学中最复杂的大分子组装体之一。过去十年的研究有助于让肌节呈现出全新面貌，因此，肌节正被重新定义为一个动态的蛋白质网络，它能够产生力量，并与其他细胞区室和代谢酶进行信号传导，而这些代谢酶能够控制横纹肌细胞生物学的许多方面。
