川崎病复发病例的心脏后遗症。
Cardiac sequelae of Kawasaki disease among recurrent cases.
作者信息
Nakamura Y, Yanagawa H, Ojima T, Kawasaki T, Kato H
机构信息
Department of Public Health, Jichi Medical School, Tochigi, Japan.
出版信息
Arch Dis Child. 1998 Feb;78(2):163-5. doi: 10.1136/adc.78.2.163.
OBJECTIVE
This study was undertaken to clarify whether cardiac sequelae due to Kawasaki disease are more frequent among recurrent cases than initial onset cases.
STUDY DESIGN
A cross sectional study using data from nationwide surveys of Kawasaki disease in Japan was conducted. A total of 33,976 patients reported were divided into two groups: initial onset cases (32,923 patients) and recurrent cases (1053 patients). Proportions of cardiac sequelae such as coronary aneurysms/dilatation, coronary stenosis/narrowing, myocardial infarction, and valvular lesions were compared between the two groups.
RESULTS
The proportions of patients with the sequelae were significantly more common among recurrent cases. In men 25.5% of the recurrent cases had the sequelae in comparison with 14.9% for initial onset cases, and in women 16.1% of recurrent cases had the sequelae compared with 9.8% of initial onset cases. Giant coronary aneurysms were twice as likely in men in whom the disease was recurring than in initial onset cases, and 1.5 times more likely in women in whom the disease was recurring than in initial onset cases.
CONCLUSION
Cardiac sequelae of Kawasaki disease are more likely to appear on recurrent case patients.
目的
本研究旨在阐明川崎病的心脏后遗症在复发病例中是否比初发病例更常见。
研究设计
采用日本全国川崎病调查数据进行横断面研究。报告的33976例患者分为两组：初发病例（32923例）和复发病例（1053例）。比较两组中心脏后遗症如冠状动脉瘤/扩张、冠状动脉狭窄/缩窄、心肌梗死和瓣膜病变的比例。
结果
后遗症患者的比例在复发病例中显著更常见。男性中25.5%的复发病例有后遗症，而初发病例为14.9%；女性中16.1%的复发病例有后遗症，初发病例为9.8%。巨大冠状动脉瘤在复发男性中的发生可能性是初发病例的两倍，在复发女性中的发生可能性是初发病例的1.5倍。
结论
川崎病的心脏后遗症更易出现在复发病例患者中。
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