Clearman D R, Jacobs D R
Reuben Berman Center for Clinical Research, Metropolitan-Mount Sinai Medical Center, Minneapolis, MN.
Addict Behav. 1991;16(6):401-10. doi: 10.1016/0306-4603(91)90048-m.
Data from 6,569 middle-aged men in the Multiple Risk Factor Intervention Trial were analyzed to determine whether the weight change associated with smoking cessation resulted primarily from appetite or metabolic alterations. The appetite hypothesis attributes weight gain to an enhanced appetite and subsequent increase in caloric intake. The metabolic change hypothesis attributes weight gain to a metabolic alteration and subsequent decrease in basic caloric needs. Caloric intake and weight changes were tabulated for men who quit smoking and were compared to similar changes in men who continued smoking over 12 months. The difference between caloric intake changes in men quitting smoking versus men continuing smoking, controlled for weight change, was attributed to the metabolic change hypothesis. Men who quit smoking consumed 103 calories per day less (95% confidence interval = 29 to 177) than men who continued smoking with similar body weight changes. The decrease in caloric intake attributed to smoking cessation was proportional to the number of cigarettes smoked prior to cessation [corrected].
对多重危险因素干预试验中6569名中年男性的数据进行了分析，以确定与戒烟相关的体重变化主要是由食欲还是代谢改变引起的。食欲假说将体重增加归因于食欲增强及随后热量摄入增加。代谢变化假说将体重增加归因于代谢改变及随后基础热量需求减少。对戒烟男性的热量摄入和体重变化进行列表，并与持续吸烟12个月的男性的类似变化进行比较。在控制体重变化的情况下，戒烟男性与持续吸烟男性热量摄入变化的差异归因于代谢变化假说。体重变化相似的情况下，戒烟男性比持续吸烟男性每天少摄入103卡路里（95%置信区间=29至177）。归因于戒烟的热量摄入减少与戒烟前吸烟的数量成正比[校正后]。
