Iioka H, Akada S, Hisanaga H, Shimamoto T, Yamada Y, Moriyama I S, Ichijo M
Department of Obstetrics and Gynaecology, Nara Medical University, Japan.
Asia Oceania J Obstet Gynaecol. 1991 Dec;17(4):357-61. doi: 10.1111/j.1447-0756.1991.tb00286.x.
The present study was undertaken in order to determine the changes in blood levels of lipid peroxide and vitamin E during pregnancy. 1. The man plasma level of lipid peroxide was 0.89 +/- 0.13 nmole/ml for non-pregnant women, while in pregnant women it was increased as the progressed pregnancy reaching 2.71 +/- 0.29 nmole/ml at full term. 2. The mean plasma, red cell and platelet levels of vitamin E were 6.6 +/- 0.9 micrograms/ml, 3.55 +/- 0.38 micrograms/ml packed cell and 99 +/- 25 micrograms/g protein for non-pregnant women, while in pregnant women the levels changed as the progressed pregnancy becoming 15.5 +/- 0.9 micrograms/ml, 2.43 +/- 0.24 micrograms/ml packed cell, and 244 +/- 19 micrograms/g protein at full term. It was shown in this study that during pregnancy the plasma level of lipid peroxide increased while the levels of vitamin E which inhibited the formation of lipid peroxide, increased in plasma and platelets, but decreased in red cells.
本研究旨在确定孕期脂质过氧化物和维生素E血液水平的变化。1. 非孕期女性血浆脂质过氧化物水平为0.89±0.13纳摩尔/毫升，而孕期女性随着孕期进展该水平升高，足月时达到2.71±0.29纳摩尔/毫升。2. 非孕期女性血浆、红细胞和血小板中维生素E的平均水平分别为6.6±0.9微克/毫升、3.55±0.38微克/毫升（压积细胞）和99±25微克/克蛋白质，而孕期女性这些水平随孕期进展而变化，足月时分别变为15.5±0.9微克/毫升、2.43±0.24微克/毫升（压积细胞）和244±19微克/克蛋白质。本研究表明，孕期血浆脂质过氧化物水平升高，而抑制脂质过氧化物形成的维生素E水平在血浆和血小板中升高，但在红细胞中降低。
