Iioka H
Department of Obstetrics and Gynecology, Nara Medical University, Japan.
Gynecol Obstet Invest. 1994;38(3):173-6. doi: 10.1159/000292473.
The present study was undertaken in order to determine the changes in blood levels of lipid peroxide and vitamin E in EPH gestosis. The mean plasma level of lipid peroxide was 0.89 +/- 0.13 nmol/ml for nonpregnant women, while for normal pregnant women it was 2.51 +/- 0.52 nmol/ml, and 4.10 +/- 0.72 nmol/ml for women with EPH gestosis. The mean plasma level of vitamin E was 6.7 +/- 1.0 micrograms/ml for nonpregnant women, while for normal pregnant women it was 14.5 +/- 2.2 micrograms/ml and 12.6 +/- 1.2 micrograms/ml for women with gestosis. The mean red cell level of vitamin E was 3.55 +/- 0.25 micrograms/ml packed red cells in nonpregnant women, while in normal pregnant women it was 2.56 +/- 0.34 micrograms/ml packed cells and 2.90 +/- 0.28 micrograms/ml packed cells for women with EPH gestosis. The mean platelet level of vitamin E was 99 +/- 25 micrograms/g protein for nonpregnant women, while in normal pregnant women it was 232 +/- 24 micrograms/ml protein and 205 +/- 32 micrograms/g protein for women with EPH gestosis. It was shown in this study that in EPH gestosis the plasma level of lipid peroxide increased while the levels of vitamin E which inhibited the formation of lipid peroxide decreased in plasma, red cells and platelets.
本研究旨在确定妊娠高血压综合征（EPH 妊娠中毒症）患者血液中脂质过氧化物和维生素 E 水平的变化。非孕妇血浆中脂质过氧化物的平均水平为 0.89±0.13 nmol/ml，正常孕妇为 2.51±0.52 nmol/ml，EPH 妊娠中毒症患者为 4.10±0.72 nmol/ml。非孕妇血浆中维生素 E 的平均水平为 6.7±1.0 微克/ml，正常孕妇为 14.5±2.2 微克/ml，妊娠中毒症患者为 12.6±1.2 微克/ml。非孕妇红细胞中维生素 E 的平均水平为每毫升压积红细胞 3.55±0.25 微克，正常孕妇为 2.56±0.34 微克/ml 压积细胞，EPH 妊娠中毒症患者为 2.90±0.28 微克/ml 压积细胞。非孕妇血小板中维生素 E 的平均水平为 99±25 微克/克蛋白质，正常孕妇为 232±24 微克/ml 蛋白质，EPH 妊娠中毒症患者为 205±32 微克/克蛋白质。本研究表明，在 EPH 妊娠中毒症中，血浆中脂质过氧化物水平升高，而抑制脂质过氧化物形成的维生素 E 在血浆、红细胞和血小板中的水平降低。
