Fong D, Chan M M, Hsieh W T
Department of Biological Sciences, Rutgers State University of New Jersey, Piscataway 08855-1059.
Biomed Biochim Acta. 1991;50(4-6):595-8.
Chromosomal locations of human cathepsin B, stefin A and kininogen have been determined. Using techniques of somatic cell hybrids and polymerase chain reaction, cathepsin B has been mapped to 8p22, stefin A to 3cen-q21, and kininogen to 3q26-qter. Comparing this data with currently available mapping loci, it can be concluded that many members of cathepsins are dispersed in different chromosomes, whereas members of the cystatin family are restricted to only two human chromosomes, 3 and 20.
已确定人组织蛋白酶B、丝抑蛋白A和激肽原的染色体定位。利用体细胞杂交技术和聚合酶链反应，组织蛋白酶B被定位到8p22，丝抑蛋白A被定位到3cen-q21，激肽原被定位到3q26-qter。将该数据与目前可用的定位位点进行比较，可以得出结论，组织蛋白酶家族的许多成员分散在不同的染色体上，而半胱氨酸蛋白酶抑制剂家族的成员仅局限于人类的两条染色体，即3号和20号染色体。
