通过使用聚合酶链反应对体细胞杂种进行分析，将人类激肽原基因（KNG）定位到3号染色体的q26 - qter区域。
The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic cell hybrids using the polymerase chain reaction.
作者信息
Fong D, Smith D I, Hsieh W T
机构信息
Department of Biological Sciences, Rutgers, State University of New Jersey, Piscataway 08855-1059.
出版信息
Hum Genet. 1991 Jun;87(2):189-92. doi: 10.1007/BF00204179.
PMID:2066106
Abstract
Kinins, peptide products of kininogens, may be involved in hypertensive and diabetic diseases, and inflammatory disorders. The human kininogen gene (KNG) has been mapped to chromosome 3, using a panel of human-hamster somatic cell hybrids by polymerase chain reaction of hybrid DNA with gene-specific primers. KNG was further assigned to 3q26-3qter, using DNA from a second panel of chromosome 3 deletion mapping cell hybrids.
摘要
激肽是激肽原的肽类产物，可能参与高血压、糖尿病及炎症性疾病。利用一组人-仓鼠体细胞杂种，通过用基因特异性引物对杂种DNA进行聚合酶链反应，已将人激肽原基因（KNG）定位于3号染色体。使用来自第二组3号染色体缺失定位细胞杂种的DNA，KNG被进一步定位于3q26 - 3qter。
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