Bai Y, Shen M Y, Zhang D F, Lai C N, Chen Y, Sun Y X, Yang Z G
Institute of Basic Medical Sciences, Beijing, PRC.
Sci China B. 1991 Nov;34(11):1319-28.
Using cell surface markers and a panel of monoclonal antibodies, 515 cases of acute lymphoblastic leukemia (ALL) were immunophenotyped. T cell type ALL (T-ALL), non-T cell type ALL (Non-T-ALL) including common ALL (C-ALL), Null-ALL and B cell type ALL (B-ALL) were found. These major subtypes of ALL were further divided according to their phenotypes in detail. It was noticed that the phenotypes of these subtypes of ALL reflected basically the phenotypes of normal T or B cells at various differentiation stages or certain population of lymphocytes. The diagnosis of cell lineage was more precise when based on immunophenotyping than morphological description. The combination of morphological and immunological classification can improve the diagnosis of acute leukemias. In addition, it was observed that the immunophenotyping was relevant to clinicopathologic features, responses to therapy and prognosis of ALL patients. The incidences of major subtypes of ALL, the age distribution of ALL subsets and male sex bias with T-ALL in Chinese are discussed.
利用细胞表面标志物和一组单克隆抗体，对515例急性淋巴细胞白血病（ALL）进行了免疫表型分析。发现了T细胞型ALL（T-ALL）、非T细胞型ALL（非T-ALL），包括普通ALL（C-ALL）、裸细胞ALL和B细胞型ALL（B-ALL）。ALL的这些主要亚型根据其表型进一步详细划分。注意到ALL这些亚型的表型基本反映了正常T或B细胞在不同分化阶段或某些淋巴细胞群体的表型。基于免疫表型分析的细胞系诊断比形态学描述更精确。形态学和免疫学分类相结合可提高急性白血病的诊断水平。此外，观察到免疫表型分析与ALL患者的临床病理特征、治疗反应及预后相关。讨论了中国ALL主要亚型的发病率、ALL各亚组的年龄分布以及T-ALL的男性偏倚。
