Asproudis Ioannis, Gorezis Spiros, Aspiotis Miltiadis, Tsanou Elena, Kitsiou Evangelia, Merminga Efpraxia, Peschos Dimitrios, Charalabopoulos Konstantinos, Agnantis Niki J
Department of Ophthalmology, University Hospital of loannina, Greece.
In Vivo. 2007 Sep-Oct;21(5):909-12.
A rare case of metastatic verrucous carcinoma (VC) of the oral cavity is presented. The patient was referred to the Ophthalmology Department due to diplopia. The patient reported history of diagnosis of verrucous squamous carcinoma in the oral cavity occuring 6 years earlier that although excised presented several recurrences. The lesion metastasized to local lymph nodes and after being characterized as inoperable the patient underwent thirty-seven sessions of radiation therapy. Two months after completion of radiation therapy, the patient underwent an orbital CT scan that revealed a mass with morphological features consistent with secondary involvement of the orbit from the known VC. Although treated with chemotherapy, the patient died 5 months later. No other case of this entity, which usually presents as a slow-growing lesion enlarging with direct extension rather than frank invasion, metastasizing to the orbit has been reported in relevant literature.
本文报告了一例罕见的口腔转移性疣状癌（VC）病例。该患者因复视转诊至眼科。患者报告称，6年前曾诊断出口腔疣状鳞状癌，虽已切除但多次复发。病变转移至局部淋巴结，在被判定为无法手术切除后，患者接受了37次放射治疗。放射治疗结束两个月后，患者接受眼眶CT扫描，发现一个肿块，其形态特征与已知的VC继发眼眶受累相符。尽管接受了化疗，患者仍在5个月后死亡。相关文献中未报道过该实体的其他病例，该实体通常表现为生长缓慢的病变，通过直接蔓延而非明显浸润方式扩大，并转移至眼眶。
