Jialal I, Naiker P, Rajput M C, Naidoo C, Omar M A
Diabetes Res. 1986 Nov;3(9):479-81.
The familial aggregation and degree of adiposity of 108 Indian patients with non-insulin-dependent diabetes in the young was studied. All patients had onset of diabetes under 30 yr and the female to male ratio was 5:1. Obesity as defined was present in 52 patients (48.2%). A positive family history of diabetes was present in 90 patients (83.3%). Two distinct subtypes emerged in the patients with a positive family history; the offspring of conjugal diabetic parents (29%) and maturity onset diabetes of the young (MODY) with 3-generation transmission (13%). In conclusion, the syndrome of NIDDY in Indians comprises at least 3 subtypes: offspring of conjugal diabetic parents, MODY and patients without a family history (sporadic type).
对108例印度青年非胰岛素依赖型糖尿病患者的家族聚集性和肥胖程度进行了研究。所有患者糖尿病发病年龄均在30岁以下，男女比例为5:1。按照定义，52例患者（48.2%）存在肥胖。90例患者（83.3%）有糖尿病家族史阳性。有家族史阳性的患者中出现了两种不同的亚型：已婚糖尿病父母的后代（29%）和三代遗传的青年成熟期糖尿病（MODY）（13%）。总之，印度人非胰岛素依赖型糖尿病青年综合征至少包括3种亚型：已婚糖尿病父母的后代、MODY和无家族史的患者（散发型）。
