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1
Activation of membrane estrogen receptors induce pro-survival kinases.膜雌激素受体的激活诱导促生存激酶。
J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):97-110. doi: 10.1016/j.jsbmb.2005.08.017. Epub 2006 Jan 18.
2
Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis.雌激素受体β，一种可能参与卵巢癌发生的肿瘤抑制因子。
Cancer Lett. 2006 Jan 18;231(2):151-7. doi: 10.1016/j.canlet.2005.01.021.
3
17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection.17β-雌二醇通过L型钙通道诱导的Ca2+内流激活Src/ERK/环磷酸腺苷反应元件结合蛋白信号通路并上调大鼠海马神经元中的BCL-2表达：雌激素诱导神经保护作用的潜在起始机制
Neuroscience. 2005;135(1):59-72. doi: 10.1016/j.neuroscience.2004.12.027.
4
Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11.雌激素受体α（ERα）和β（ERβ）对正常小鼠乳腺上皮细胞系HC11的增殖和凋亡具有不同的调节作用。
Oncogene. 2005 Oct 6;24(44):6605-16. doi: 10.1038/sj.onc.1208807.
5
17-beta-estradiol elicits genomic and non-genomic responses in mouse male germ cells.17-β-雌二醇在小鼠雄性生殖细胞中引发基因组和非基因组反应。
J Cell Physiol. 2006 Jan;206(1):238-45. doi: 10.1002/jcp.20454.
6
Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells.PI3K和MAPK信号通路参与bcl-2诱导黑色素瘤细胞中血管内皮生长因子的表达。
Mol Biol Cell. 2005 Sep;16(9):4153-62. doi: 10.1091/mbc.e04-12-1087. Epub 2005 Jun 29.
7
Induction of thyroid papillary carcinoma cell proliferation by estrogen is associated with an altered expression of Bcl-xL.雌激素诱导甲状腺乳头状癌细胞增殖与Bcl-xL表达改变有关。
Cancer J. 2005 Mar-Apr;11(2):113-21. doi: 10.1097/00130404-200503000-00006.
8
Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells.膜雌激素受体α水平可预测雌激素诱导的MCF-7细胞中ERK1/2的激活。
Breast Cancer Res. 2005;7(1):R130-44. doi: 10.1186/bcr959. Epub 2004 Nov 26.
9
Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling.生存与凋亡：17β-雌二醇的作用——雌激素受体α和β激活的非基因组信号传导的作用
J Cell Physiol. 2005 Apr;203(1):193-201. doi: 10.1002/jcp.20219.
10
Heme oxygenase-1 protects against apoptosis induced by tumor necrosis factor-alpha and cycloheximide in papillary thyroid carcinoma cells.血红素加氧酶-1可保护甲状腺乳头状癌细胞免受肿瘤坏死因子-α和放线菌酮诱导的细胞凋亡。
J Cell Biochem. 2004 Aug 15;92(6):1246-56. doi: 10.1002/jcb.20157.

雌激素通过雌激素受体-ERK途径介导人甲状腺癌细胞的生长。

Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway.

作者信息

Zeng Q, Chen G G, Vlantis A C, van Hasselt C A

机构信息

Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

出版信息

Cell Prolif. 2007 Dec;40(6):921-35. doi: 10.1111/j.1365-2184.2007.00471.x.

DOI:10.1111/j.1365-2184.2007.00471.x
PMID:18021179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6495898/
Abstract

OBJECTIVES

Although thyroid cancer occurs much more frequently in females, the role of sex hormones in thyroid carcinogenesis is unknown. In this study, it has been investigated how 17beta-oestradiol (E2) influenced proliferation and growth of thyroid cancer cells.

MATERIALS AND METHODS

Cell proliferation and its related molecules were examined in thyroid papillary carcinoma cells (KAT5), follicular thyroid carcinoma cells (FRO) and anaplastic carcinoma cells (ARO). Levels of oestrogen receptor (ER) alpha and beta were regulated by their agonists (PPT and DPN), antagonists and siRNA.

RESULTS

E2 promoted cell proliferation. Such an effect was positively related to ERalpha but negatively to ERbeta; PPT enhanced cell proliferation while DPN inhibited it. PPT increased Bcl-2 expression while DPN decreased it. DPN also elevated Bax expression. PPT elevated the level of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2), suggesting a positive role of ERK1/2 in E2-induced cell proliferation. Knockdown of ERalpha significantly attenuated E2-mediated Bcl-2 and pERK1/2 expression. In contrast, knockdown of ERbeta markedly enhanced them.

CONCLUSIONS

Oestrogen stimulates proliferation of thyroid cancer cells, associated with increase in Bcl-2 and decrease in Bax levels in an ERK1/2-related pathway. Imbalance between ERalpha and ERbeta may contribute to thyroid carcinogenesis.

摘要

目的

尽管甲状腺癌在女性中更为常见，但性激素在甲状腺癌发生中的作用尚不清楚。在本研究中，已对17β-雌二醇（E2）如何影响甲状腺癌细胞的增殖和生长进行了研究。

材料与方法

在甲状腺乳头状癌细胞（KAT5）、滤泡状甲状腺癌细胞（FRO）和未分化癌细胞（ARO）中检测细胞增殖及其相关分子。雌激素受体（ER）α和β的水平通过其激动剂（PPT和DPN）、拮抗剂和小干扰RNA进行调节。

结果

E2促进细胞增殖。这种作用与ERα呈正相关，与ERβ呈负相关；PPT增强细胞增殖，而DPN抑制细胞增殖。PPT增加Bcl-2表达，而DPN降低Bcl-2表达。DPN还升高Bax表达。PPT升高磷酸化细胞外信号调节激酶1/2（pERK1/2）的水平，提示ERK1/2在E2诱导的细胞增殖中起积极作用。敲低ERα显著减弱E2介导的Bcl-2和pERK1/2表达。相反，敲低ERβ则显著增强它们的表达。

结论

雌激素刺激甲状腺癌细胞增殖，与ERK1/2相关途径中Bcl-2增加和Bax水平降低有关。ERα和ERβ之间的失衡可能导致甲状腺癌的发生。