Souza V B, Muir W J, Walker M T, Glabus M F, Roxborough H M, Sharp C W, Dunan J R, Blackwood D H
University Department of Psychiatry, Royal Edinburgh Hospital, Scotland.
Biol Psychiatry. 1995 Mar 1;37(5):300-10. doi: 10.1016/0006-3223(94)00131-L.
The auditory P300 event-related potential (ERP) and performance on neuropsychological tests were evaluated in 26 subjects with schizophrenia, 19 with bipolar affective disorder, and 27 controls. The schizophrenic and the bipolar groups were similar in having prolonged P300 latency recorded from central and temporal leads. The P300 was significantly reduced in amplitude in the schizophrenic group at midline leads and the left temporal lead but was not significantly reduced in amplitude at any electrode site when the bipolar group was compared to controls. Schizophrenics performed significantly less well than bipolars and controls on tests of verbal fluency and, within this group, a significant correlation was found between the latency of P300 and verbal fluency test scores. While the bipolar group of patients was similar to the schizophrenic group in having prolonged P300 latency, these groups differed in P300 amplitude, performance on verbal fluency tests, and the relationship between the physiological and neuropsychological variables.
对26名精神分裂症患者、19名双相情感障碍患者和27名对照者进行了听觉P300事件相关电位（ERP）和神经心理学测试表现的评估。精神分裂症组和双相情感障碍组在中央和颞叶导联记录的P300潜伏期延长方面相似。精神分裂症组中线导联和左颞叶导联的P300波幅显著降低，但双相情感障碍组与对照组相比，在任何电极部位的波幅均未显著降低。在言语流畅性测试中，精神分裂症患者的表现明显不如双相情感障碍患者和对照者，并且在该组中，发现P300潜伏期与言语流畅性测试得分之间存在显著相关性。虽然双相情感障碍患者组在P300潜伏期延长方面与精神分裂症组相似，但这些组在P300波幅、言语流畅性测试表现以及生理和神经心理学变量之间的关系方面存在差异。
