Neckers Len, Kern Adam, Tsutsumi Shinji
Urologic Oncology Branch, Center for Cancer Research, NCI, 9000 Rockville Pike, Bldg. 10/CRC, Room 1-5940, Bethesda, MD 20892, USA.
Chem Biol. 2007 Nov;14(11):1204-6. doi: 10.1016/j.chembiol.2007.11.002.
Hsp90 is a cytosolic molecular chaperone whose paralog in mitochondria, TRAP1, protects cells from oxidative stress. The recent study in Cell by Kang et al. now identifies the molecular components of the proapoptotic network regulated by TRAP1, that includes Hsp90. Targeting Hsp90/TRAP1 inhibitors to mitochondria induces rapid tumor cell-specific apoptosis.
热休克蛋白90（Hsp90）是一种胞质分子伴侣，其在线粒体中的同源物TRAP1可保护细胞免受氧化应激。Kang等人近期发表于《细胞》杂志的研究现已确定了由TRAP1调控的促凋亡网络的分子组成部分，其中包括Hsp90。将Hsp90/TRAP1抑制剂靶向线粒体可诱导肿瘤细胞快速发生特异性凋亡。
