Hodgkin Jonathan
Genetics Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
WormBook. 2005 Jun 25:1-9. doi: 10.1895/wormbook.1.3.1.
The normal karyotype of Caenorhabditis elegans, with its five pairs of autosomes and single pair of X chromosomes, is described. General features of chromosomes and global differences between different chromosomal regions are discussed. Abnormal karyotypes, including duplications, deficiencies, inversions, translocations and chromosome fusions are reviewed. The effects of varying ploidy and of varying gene dosage are summarized. Dosage-sensitive genes seem to be rare in C. elegans, and the organism is able to tolerate substantial levels of aneuploidy. However, autosomal hemizygosity for more than about 3% of the total genome may be incompatible with viability.
描述了秀丽隐杆线虫的正常核型，它有五对常染色体和一对X染色体。讨论了染色体的一般特征以及不同染色体区域之间的整体差异。综述了异常核型，包括重复、缺失、倒位、易位和染色体融合。总结了不同倍性和不同基因剂量的影响。剂量敏感基因在秀丽隐杆线虫中似乎很少见，并且该生物体能够耐受相当程度的非整倍性。然而，超过约3%的全基因组的常染色体半合子可能与生存能力不相容。
