Reue Karen, Zhang Peixiang
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.
FEBS Lett. 2008 Jan 9;582(1):90-6. doi: 10.1016/j.febslet.2007.11.014. Epub 2007 Nov 20.
The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1 alpha and PPAR alpha. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.
西方世界肥胖症的流行已将注意力集中在影响甘油三酯生物合成、储存和利用的因素上。脂素蛋白家族成员在甘油三酯和磷脂生物合成中作为磷脂酸磷酸酶具有新发现的酶促作用，并且还与过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子-1α和PPARα一起作为诱导型转录共激活因子发挥作用。通过这些活动，该家族的创始成员脂素-1影响包括脂肪组织、骨骼肌和肝脏在内的多种组织中的脂质代谢和葡萄糖稳态。脂素-2和脂素-3的生理作用尚不太明确，但可能在甘油olipid生物合成和基因表达中以不同的组织分布发挥类似功能。
