Ruf Wolfram
Department of Immunology, Scripps Research Institute, La Jolla, CA, USA.
Thromb Res. 2007;120 Suppl 2:S7-12. doi: 10.1016/S0049-3848(07)70125-1.
Tumor development depends on multiple reciprocal interactions of tumor cells with the host cell compartment. Tumor cells initiate TF-dependent crosstalks with the tumor microenvironment by releasing procoagulant microparticles, soluble cytokines and angiogenic growth factors. Conversely, the hemostatic system in the host compartment provides multiple circuits that regulate tumor growth and sustain angiogenesis. A combination of experimental models of spontaneous and transplanted tumor development and metastasis start to delineate the role of TF in tumor progression and identified potential therapeutic approaches to target the TF pathway.
肿瘤的发展取决于肿瘤细胞与宿主细胞区室之间的多种相互作用。肿瘤细胞通过释放促凝微粒、可溶性细胞因子和血管生成生长因子，启动与肿瘤微环境的组织因子（TF）依赖性串扰。相反，宿主区室中的止血系统提供了多个调节肿瘤生长和维持血管生成的回路。自发性和移植性肿瘤发展及转移的实验模型相结合，开始阐明TF在肿瘤进展中的作用，并确定了靶向TF途径的潜在治疗方法。
