仙台病毒感染细胞中多核糖体形成和蛋白质合成的增强。

Enhancement of polysome formation and protein synthesis in Sendai virus-infected cells.

作者信息

Zaides V M, Selimova L M, Nicolaeva O G, Bukrinskaya A G

出版信息

J Gen Virol. 1976 May;31(2):193-7. doi: 10.1099/0022-1317-31-2-193.

Abstract

A considerable stimulation of total protein synthesis in Sendai virus-infected chicken fibroblasts occurred 18 h after infection. The stimulation of synthesis was shown to be due mainly to the synthesis of virus-specific proteins; the synthesis of host proteins was either unchanged or slightly enhanced. The level of functional polyribosomes in virus-infected cells was also increased as compared to that in mock-infected control while the number of free 80S ribosomes was proportionally decreased.

摘要

在仙台病毒感染鸡成纤维细胞18小时后，总蛋白合成受到显著刺激。结果表明，合成的刺激主要归因于病毒特异性蛋白的合成；宿主蛋白的合成要么未发生变化，要么略有增强。与模拟感染对照组相比，病毒感染细胞中功能性多核糖体的水平也有所增加，而游离80S核糖体的数量则相应减少。