Liem Robert I, Young Luciana T, Thompson Alexis A
Division of Hematology, Oncology & Stem Cell Transplant, Children's Memorial Hospital, 2300 Children's Plaza, Box 30, Chicago, IL 60614-3394, USA.
Haematologica. 2007 Nov;92(11):1549-52. doi: 10.3324/haematol.11576.
Tricuspid regurgitant jet velocity (TRJV) >or= 2.5 m/sec. on echocardiography is a surrogate marker for pulmonary hypertension (PHT) in adults with sickle cell disease (SCD). We prospectively examined the relationship between TRJV and laboratory markers of hemolysis in 51 children and young adults with SCD at baseline. We found significant correlations between TRJV and lactate dehydrogenase (LDH), hemoglobin (Hb), reticulocyte count (retic) and aspartate aminotransferase (AST). LDH, retic and AST were significantly higher and Hb was lower in subjects with TRJV >or= 2.5 m/sec. We conclude that hemolysis significantly contributes to TRJV elevation in children and young adults with SCD.
超声心动图显示三尖瓣反流射流速度（TRJV）≥2.5米/秒是镰状细胞病（SCD）成年患者肺动脉高压（PHT）的替代标志物。我们前瞻性地研究了51例SCD儿童和青年患者基线时TRJV与溶血实验室指标之间的关系。我们发现TRJV与乳酸脱氢酶（LDH）、血红蛋白（Hb）、网织红细胞计数（retic）和天冬氨酸转氨酶（AST）之间存在显著相关性。TRJV≥2.5米/秒的患者中，LDH、retic和AST显著升高，Hb降低。我们得出结论，溶血在SCD儿童和青年患者TRJV升高中起显著作用。
