Paul Anindita, Samal Priyanka, Behera Kumar Gaurav, Patra Pritish Chandra, Samal Ashutosh, Bishoyi Ajit Kumar, Pradhan Sarita
Department of Clinical Hematology, Institute of Medical Sciences & Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha 751003 India.
Department of Cardiology, Institute of Medical Sciences & Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha 751003 India.
Indian J Hematol Blood Transfus. 2025 Apr;41(2):377-382. doi: 10.1007/s12288-024-01772-4. Epub 2024 May 8.
To study the prevalence of pulmonary arterial hypertension (PAH) in individuals with sickle cell disease (SCD) and its relationship with serological markers. Data of ninety-two SCD patients who visited the Department of Clinical Haematology between 2020 and 2021 was retrieved through the hospital record system. These patients underwent laboratory testing, including a clinical evaluation was done at baseline. They underwent Doppler echocardiography to determine the maximum tricuspid regurgitation jet velocity. Among 92 patients, 43 were men and 49 were female, with the mean age being 29.9 ± 8.8 years. Using Doppler echocardiography, their pulmonary artery systolic pressure was determined. Pulmonary arterial hypertension was found in 29 out of 92 patients (31.5%). The prevalence of PAH was 20.9% in males and 40.8% in women. A significant association was shown with females (p = 0.041.) There was a positive correlation with hemolytic markers, including reticulocyte count (r = 0.212, p < 0.05), lactate dehydrogenase (r = 0.322, p < 0.01 with tricuspid regurgitation velocity (TRvmax) (r = 0.322, p < 0.01) along with NT-ProBNP (r = 0.310, p < 0.01). The maximal tricuspid regurgitation velocity and haemoglobin concentration had a negative correlation. (r = -0.340, p < 0.01). In resource-limited settings, NT Pro BNP and transthoracic echocardiography can be used as screening tools for pulmonary hypertension in SCD.
研究镰状细胞病（SCD）患者中肺动脉高压（PAH）的患病率及其与血清学标志物的关系。通过医院记录系统检索了2020年至2021年间到临床血液科就诊的92例SCD患者的数据。这些患者接受了实验室检查，包括在基线时进行临床评估。他们接受了多普勒超声心动图检查以确定三尖瓣反流最大射流速度。92例患者中，男性43例，女性49例，平均年龄为29.9±8.8岁。使用多普勒超声心动图测定他们的肺动脉收缩压。92例患者中有29例（31.5%）发现患有肺动脉高压。PAH在男性中的患病率为20.9%，在女性中的患病率为40.8%。女性显示出显著相关性（p = 0.041）。与溶血标志物存在正相关，包括网织红细胞计数（r = 0.212，p < 0.05）、乳酸脱氢酶（r = 0.322，p < 0.01），与三尖瓣反流速度（TRvmax）（r = 0.322，p < 0.01）以及N末端B型钠尿肽原（r = 0.310，p < 0.01）。三尖瓣反流最大速度与血红蛋白浓度呈负相关（r = -0.340，p < 0.01）。在资源有限的环境中，N末端B型钠尿肽原和经胸超声心动图可作为SCD患者肺动脉高压的筛查工具。
