镰状细胞病中肺动脉高压的全球负担：一项系统评价和荟萃分析。
The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis.
作者信息
Musa B M, Galadanci N A, Coker M, Bussell S, Aliyu M H
机构信息
Department of Medicine, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
Department of Hematology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
出版信息
Ann Hematol. 2016 Oct;95(11):1757-64. doi: 10.1007/s00277-016-2693-z. Epub 2016 May 16.
Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5-27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7--25.6) and 24.4 % (95 % CI 18.4-30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.
三尖瓣反流喷射速度（TRJV）升高是镰状细胞病（SCD）患者肺动脉高压（PH）的替代指标。我们试图根据TRJV评估镰状细胞病患者的肺动脉高压负担。2000年至2015年，我们在电子数据库中检索符合条件的出版物，纳入了29项研究（n = 5358人）。我们使用随机效应模型来确定TRJV升高的合并估计值。SCD患者中TRJV升高的总体合并患病率为23.5%（95%CI 19.5 - 27.4）。SCD儿童和成人中TRJV升高的合并患病率分别为20.7%（95%CI 15.7 - 25.6）和24.4%（95%CI 18.4 - 30.4）。TRJV在SCD成人和儿童中普遍存在。我们的研究结果支持国际上呼吁对SCD患者进行肺动脉高压筛查的建议。
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