Abid S H, Khoobyarian N
J Gen Virol. 1976 Jun;31(3):437-40. doi: 10.1099/0022-1317-31-3-437.
The purified fibre and hexon of adenovirus 12 inhibit the transformation in tissue culture of murine sarcoma virus (msv-m) by as much as 80% and 70%, respectively, when they are added to cells 8 to 2o h before MSV-M infection. During a 12 h period, only about 6 to 8% of added radiolabelled viral proteins become associated with cells (or I-O mug protein bound/10(5) cells). No inhibition occurs when the proteins are added simultaneously with MSV-M or 90 min or 4 h after MSV-M. There is also a direct correlation between the extent of focus inhibition and the concentrations of viral proteins used. Concentrations of viral proteins used to inhibit cell transformation do not affect cell growth, but do reduce cell macromolecular synthesis.
当在感染MSV-M前8至20小时将纯化的腺病毒12纤维蛋白和六邻体蛋白添加到细胞中时，它们分别能抑制鼠肉瘤病毒（msv-m）在组织培养中的转化达80%和70%。在12小时内，只有约6%至8%的添加放射性标记病毒蛋白与细胞结合（即每10⁵个细胞结合1.0微克蛋白）。当这些蛋白与MSV-M同时添加或在MSV-M感染后90分钟或4小时添加时，不会产生抑制作用。病灶抑制程度与所用病毒蛋白浓度之间也存在直接相关性。用于抑制细胞转化的病毒蛋白浓度不影响细胞生长，但会减少细胞大分子合成。
