Bhatt Surya Prakash, Luqman-Arafath T K, Guleria Randeep
Department of Internal Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Indian J Med Sci. 2007 Nov;61(11):616-24.
Hypertension is a silent killer. Indians are racially predisposed to cardiovascular disease and the increasing burden of hypertension has only added to the problem. Economic constraints and the allure of additional benefits without adverse effects have made lifestyle modifications an attractive proposition in developing and developed countries alike. Blood pressure is a continuum and any increase above optimal confers additional independent risk of vascular disease, even in ranges previously considered normal. While antihypertensive agents have been used for those patients with blood pressure above the traditional cutoff, there has been increasing emphasis on the prevention and treatment of hypertension by non-pharmacological means, termed 'lifestyle modifications.' A MEDLINE search was done for relevant references with emphasis on original studies, randomized controlled trials and meta-analyses. Lifestyle modifications that effectively lower blood pressure are increased physical activity, weight loss, limited alcohol consumption, reduced sodium intake and the Dietary Approaches to Stop Hypertension diet. Lifestyle modification is recommended as initial therapy in stage 1 hypertension before initiation of drug therapy and as an adjunct to medication in persons already on drug therapy. In pre-hypertensives, it can reduce the incidence of hypertension and lower end-organ damage. It is emphasized that simple advice from physicians can have a positive influence on patients' motivation to make lifestyle changes.
高血压是个无声的杀手。印度人在种族上易患心血管疾病,而不断增加的高血压负担更是雪上加霜。经济限制以及无不良影响却有额外益处的诱惑,使得生活方式改变在发展中国家和发达国家都成为了一个颇具吸引力的提议。血压是一个连续变量,即使在之前被认为正常的范围内,任何高于最佳值的血压升高都会带来额外的独立血管疾病风险。虽然抗高血压药物已用于血压高于传统临界值的患者,但人们越来越强调通过非药物手段预防和治疗高血压,即所谓的“生活方式改变”。我们在医学文献数据库(MEDLINE)中进行了检索,重点查找相关参考文献,尤其是原创研究、随机对照试验和荟萃分析。能有效降低血压的生活方式改变包括增加体力活动、减轻体重、限制饮酒、减少钠摄入以及采用终止高血压膳食疗法(DASH饮食)。生活方式改变被推荐为1级高血压患者在开始药物治疗前的初始治疗方法,以及已接受药物治疗患者的辅助治疗手段。对于血压正常高值者,它可以降低高血压的发病率并减少靶器官损害。需要强调的是,医生的简单建议会对患者做出生活方式改变的积极性产生积极影响。