Gorur Sadik, Inanoglu Kerem, Akkurt B Cagla O, Candan Yasar, Kiper Ahmet N
Department of Urology, Mustafa Kemal University, School of Medicine, Antakya/Hatay, Turkey.
Urol Int. 2007;79(4):297-301. doi: 10.1159/000109712.
To evaluate the effects of periprostatic bupivacaine administration on pain control and analgesic consumption after transurethral prostate resection (TURP).
The study included 40 male patients with benign prostatic hyperplasia who underwent TURP, and they were divided randomly into two groups. All patients were operated under general anesthesia. The study group patients (n = 20) received periprostatic bupivacaine (0.5% 20 ml) injection (group I), and the control patients (n = 20) received only saline (NaCl 0.9% 20 ml) injection (group II). All injections were performed bilaterally into the periprostatic areas immediately after the TURP procedure via the transperineal route. In the postoperative period, all patients (groups I and II) received tramadol using a patient-controlled analgesia device. Postoperative pain was assessed and recorded using the visual analog scale (VAS) at postoperative hours 1, 2, 3, 4, 5, 6, 7, 8, 12, 16, 20, 24, and 48. Total tramadol consumptions and additional analgesic requirements were also recorded and compared between groups.
There was no difference in demographic data between the two groups (p > 0.05). VAS scores of the patients at hours 1, 3, 4, 5, 7, 8, and 12 were found to be significantly lower in group I than in group II (p < 0.05). Total tramadol consumption and patient-controlled analgesia demands of groups I and II were 153.5 +/- 52.4 vs. 465.0 +/- 55.1 mg and 17.1 +/- 7.7 vs. 77.8 +/- 7.5 mg, respectively (p < 0.001). No side effect was observed regarding bupivacaine injections.
Periprostatic bupivacaine administration was a useful and safe method for postoperative pain control and reduced analgesic consumption in patients undergoing TURP.
评估经尿道前列腺切除术（TURP）后前列腺周围注射布比卡因对疼痛控制和镇痛药物使用的影响。
该研究纳入了40例接受TURP的良性前列腺增生男性患者，随机分为两组。所有患者均在全身麻醉下手术。研究组患者（n = 20）接受前列腺周围布比卡因（0.5% 20 ml）注射（I组），对照组患者（n = 20）仅接受生理盐水（0.9% NaCl 20 ml）注射（II组）。所有注射均在TURP手术后立即经会阴途径双侧注入前列腺周围区域。术后，所有患者（I组和II组）均使用患者自控镇痛装置给予曲马多。术后1、2、3、4、5、6、7、8、12、16、20、24和48小时，使用视觉模拟评分法（VAS）评估并记录术后疼痛情况。记录并比较两组的曲马多总用量和额外镇痛需求。
两组患者的人口统计学数据无差异（p > 0.05）。发现I组患者在术后1、3、4、5、7、8和12小时的VAS评分显著低于II组（p < 0.05）。I组和II组的曲马多总用量及患者自控镇痛需求分别为153.5±52.4 vs. 465.0±55.1 mg和17.1±7.7 vs. 77.8±7.5 mg（p < 0.001）。未观察到布比卡因注射的副作用。
前列腺周围注射布比卡因是TURP患者术后疼痛控制和减少镇痛药物使用的一种有效且安全的方法。
