Gotlieb-Stematsky T, Arlazoroff A
J Neurol Sci. 1976 May;28(1):115-20. doi: 10.1016/0022-510x(76)90052-6.
An association of evidence of Epstein-Barr virus (EBV) infection in 3 different cases of neurological disease not related to infectious monomucleosis is reported. A rise in antibody titres to EBV-viral capsid antigen (VCA) and early antigen (EA) in the serum and CSF was demonstrated in a patient with acute encephalitis and in a patient with a psychotic-like organic brain syndrome. Both patients demonstrated albuminocytological dissociation in the cerebrospinal fluid. IgM antibodies specific to EBV-VCA indicating a primary infection by EBV were found in both patients. In the second, concomitant infection with HSV1 probably preceding EBV infection was found. In the third patient with polyneuritis, elevated antibody titres to EBV-VCA were demonstrated. No evidence of penetration of antibodies to EBV through the blood-brain barrier, resulting from the elevated level in the serum, was demonstrated.
据报道，在3例与传染性单核细胞增多症无关的神经系统疾病病例中发现了爱泼斯坦-巴尔病毒（EBV）感染的证据。在1例急性脑炎患者和1例患有类精神病性器质性脑综合征的患者中，血清和脑脊液中针对EBV病毒衣壳抗原（VCA）和早期抗原（EA）的抗体滴度升高。两名患者脑脊液均显示蛋白细胞分离。两名患者均发现了针对EBV-VCA的特异性IgM抗体，表明存在EBV原发性感染。在第二例患者中，发现可能先于EBV感染的单纯疱疹病毒1型（HSV1）合并感染。在第三例患有多发性神经炎的患者中，检测到针对EBV-VCA的抗体滴度升高。未发现血清中抗体水平升高导致EBV抗体穿透血脑屏障的证据。
