Yabuki S, Kazahaya Y, Kubonishi I
Folia Psychiatr Neurol Jpn. 1985;39(1):85-93. doi: 10.1111/j.1440-1819.1985.tb01947.x.
Antibody titers to the Epstein-Barr virus (EBV) in the serum and cerebrospinal fluid (CSF) were determined in 57 cases of acute or subacute neurological diseases. As a result, sera from 11 cases (7 Bell's palsy, 2 encephalitis and 2 acute cerebellar ataxia) were found to be positive for antibodies to early antigen. Seven of these 11 cases either seroconverted for IgG antibodies to viral capsid antigen (VCA) or were proven positive for anti-VCA-IgM antibodies in the serum. While 4 were found positive for IgG antibodies to VCA in CSF, 3 tested by the anti-complement immunofluorescence method were all negative for EBV-associated nuclear antigen (EBNA) in CSF. Three of the 11 cases were considered to be of a primary infection with EBV because of a negative serologic test for antibodies to EBNA initially; a reinfection with the virus or a reactivation of the latent infection was suspected in some of the remaining cases.
对57例急性或亚急性神经疾病患者的血清和脑脊液（CSF）中的爱泼斯坦-巴尔病毒（EBV）抗体滴度进行了测定。结果发现，11例患者（7例贝尔麻痹、2例脑炎和2例急性小脑共济失调）的血清中早期抗原抗体呈阳性。这11例患者中有7例血清中针对病毒衣壳抗原（VCA）的IgG抗体发生了血清转化，或者血清中抗VCA-IgM抗体被证实呈阳性。虽然在脑脊液中发现4例针对VCA的IgG抗体呈阳性，但通过抗补体免疫荧光法检测的3例脑脊液中EBV相关核抗原（EBNA）均为阴性。11例患者中有3例最初EBNA抗体血清学检测为阴性，被认为是EBV原发性感染；其余部分病例怀疑是病毒再感染或潜伏感染再激活。
