1型、2型和3型脊髓小脑共济失调：心率变异性研究
Spinocerebellar ataxias type 1, 2 and 3: a study of heart rate variability.
作者信息
Pradhan C, Yashavantha B S, Pal P K, Sathyaprabha T N
机构信息
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
出版信息
Acta Neurol Scand. 2008 May;117(5):337-42. doi: 10.1111/j.1600-0404.2007.00945.x. Epub 2007 Nov 19.
OBJECTIVE
To detect cardiac autonomic dysfunction, using analysis of heart rate variability in genetically defined spinocerebellar ataxias (SCA).
MATERIALS AND METHODS
Consecutive RR intervals were analyzed for time- and frequency-domain parameters in 22 genotypically proven SCA patients (SCA1 = 11, SCA2 = 6 and SCA3 = 5) and compared with that of age- and gender-matched controls.
RESULTS
Reduction in the standard deviation of RR interval (RR_SD) was seen in 72.7% of SCA patients. There was a reduction in both the parasympathetic and sympathetic parameters in SCA without any change in the ratio of low- to high-frequency power. In SCA1, there was a significant negative correlation between RR_SD and duration of illness but not with the CAG repeat lengths of the abnormal allele. Small sample size of SCA2 and SCA3 precluded similar comparison.
CONCLUSIONS
Cardiac autonomic dysfunction, predominantly parasympathetic, was seen in SCA, and the severity correlated with the duration of illness in SCA1.
目的
通过分析基因明确的脊髓小脑共济失调（SCA）患者的心率变异性来检测心脏自主神经功能障碍。
材料与方法
对22例基因分型确诊的SCA患者（SCA1 = 11例、SCA2 = 6例和SCA3 = 5例）的连续RR间期进行时域和频域参数分析，并与年龄和性别匹配的对照组进行比较。
结果
72.7%的SCA患者RR间期标准差（RR_SD）降低。SCA患者的副交感神经和交感神经参数均降低，低频与高频功率比值无变化。在SCA1中，RR_SD与病程呈显著负相关，但与异常等位基因的CAG重复长度无关。SCA2和SCA3样本量小，无法进行类似比较。
结论
SCA患者存在心脏自主神经功能障碍，主要为副交感神经功能障碍，且SCA1中其严重程度与病程相关。
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