马查多-约瑟夫病患者心率变异性的频谱分析。

Spectral analysis of heart rate variability in patients with Machado-Joseph disease.

机构信息

Department of Neurology, Chiba University School of Medicine, Chiba, Japan.

出版信息

Auton Neurosci. 2010 Apr 19;154(1-2):99-101. doi: 10.1016/j.autneu.2009.11.008. Epub 2010 Jan 8.

DOI:10.1016/j.autneu.2009.11.008

PMID:20060786

Abstract

OBJECTIVE

Tachycardia is a clinical feature of Machado-Joseph disease (MJD), and it may be attributable to cardiac autonomic dysfunction. We investigated heart rate variability in MJD patients to reveal heart rate dysregulation in MJD.

METHODS

Power spectral analysis of successive R-R intervals (300 beats) was performed in 10 genetically diagnosed MJD patients and 10 healthy control subjects to obtain frequency-domain measures, including high- (HF; 0.15-0.4 Hz) and low frequency power (LF; 0.04-0.15 Hz) and the ratio of LF to HF (LF/HF) of heart rate variability. In addition, the coefficient of R-R intervals (CV(R-R)) was calculated as a time-domain measure.

RESULTS

HF in the MJD patients (26.2+/-25.3 ms(2)) was lower than that in the controls (82.1+/-82.6 ms(2), p=0.004). LF was also lower in the MJD patients (70.6+/-69.4 ms(2)) than in the controls (106.9+/-81.3 ms(2); p=0.029). There was no significant difference in LF/HF or CV(R-R) between the groups.

CONCLUSION

HF, which is modulated by parasympathetic vagal activity, was low in our MJD patients. The reduced parasympathetic activity may be a cause of tachycardia in MJD patients.

摘要

目的

心动过速是 Machado-Joseph 病（MJD）的一种临床特征，可能归因于心脏自主神经功能障碍。我们研究了 MJD 患者的心率变异性，以揭示 MJD 中的心率失调。

方法

对 10 名经基因诊断的 MJD 患者和 10 名健康对照者进行连续 R-R 间期（300 次）的功率谱分析，以获得频域指标，包括心率变异性的高频（HF；0.15-0.4 Hz）和低频功率（LF；0.04-0.15 Hz）以及 LF 与 HF 的比值（LF/HF）。此外，计算 R-R 间期的系数（CV（R-R））作为时域指标。

结果

MJD 患者的 HF（26.2+/-25.3 ms（2））低于对照组（82.1+/-82.6 ms（2），p=0.004）。MJD 患者的 LF 也较低（70.6+/-69.4 ms（2））低于对照组（106.9+/-81.3 ms（2）；p=0.029）。两组间 LF/HF 或 CV（R-R）无显著差异。