Lewitzka U, Müller-Oerlinghausen B, Felber W, Brunner J, Hawellek B, Rujescu D, Ising M, Lauterbach E, Broocks A, Bondy B, Rao M L, Frahnert C, Heuser I, Hohagen F, Maier W, Bronisch T
Department of Psychiatry and Psychotherapy, Technical University of Dresden, Dresden, Germany.
Acta Psychiatr Scand. 2008 Jan;117(1):41-9. doi: 10.1111/j.1600-0447.2007.01121.x. Epub 2007 Nov 19.
Low platelet monoaminoxidase B (MAO-B) activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls.
In 87 patients with affective spectrum disorders (58% suffering from a major depressive episode - MDE) the potential association between platelet MAO-B activity and suicidality was examined. Fifty-nine of the patients had committed suicide attempt recently (SA -'suicide attempters'), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA -'non-suicide attempters').
The SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a single finding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the SA was observed.
Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated.
血小板单胺氧化酶B（MAO - B）活性降低与多种冲动行为及自杀倾向有关。本研究调查了血小板MAO - B活性与抑郁症患者及对照组自杀倾向各方面之间的关系。
对87例情感谱系障碍患者（58%患有重度抑郁发作 - MDE），研究血小板MAO - B活性与自杀倾向之间的潜在关联。其中59例患者近期有自杀未遂经历（SA - “自杀未遂者”），28例患者为急性抑郁，既往无自杀念头或自杀行为（NA - “非自杀未遂者”）。
SA组和NA组在诊断、一般人口统计学及精神病理学参数方面具有可比性。SA组和NA组之间的MAO - B活性无差异。MAO - B活性与自杀行为或精神病理学的任何维度均无系统相关性。唯一的一项发现是，SA组中较高的MAO - B活性与SA的致死意图之间存在微弱的正相关。
我们的研究结果总体上不支持血小板MAO - B活性与自杀行为之间存在一致关联，但自杀倾向的某些特定因素可能与之相关。
